GNE-6640

GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2].

Product Specifications

CAS Number

[2009273-67-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GNE-6640.html

Purity

99.91

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1

Molecular Formula

C20H18N4O

Molecular Weight

330.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550 (7677) :534-538.|[2]Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85 (4) :627-639.