CUDA

CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].

Product Specifications

CAS Number

[479413-68-8]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Epoxide Hydrolase; PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cuda.html

Purity

99.83

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1CCCCC1)NCCCCCCCCCCCC(O)=O

Molecular Formula

C19H36N2O3

Molecular Weight

340.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Morisseau C, et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 1;63 (9) :1599-608.|[2]Fang X, et al. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul;314 (1) :260-70.