Tripamide
Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent[1].
Product Specifications
CAS Number
[73803-48-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tripamide.html
Purity
98.78
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(C(C=C1)=CC([S](N)(=O)=O)=C1Cl)NN2C[C@@]3([H])[C@](C2)([H])[C@@H]4C[C@H]3CC4
Molecular Formula
C16H20ClN3O3S
Molecular Weight
369.87
Precautions
H302, H315, H319, H335
References & Citations
[1]H Asada, et al. Effects of N- (4-azo-endo-tricyclo[5.2.1.0. (2.6) ]-decan-4-yl) -4-chloro-3-sulfamoylbenzamide (E614; tripamide) on vascular smooth muscles. Gen Pharmaco. 1982;13 (3) :215-23.|[2]Philip Hampel, et al. Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Sci Rep. 2018 Jun 29;8 (1) :9877.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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