SRPIN803

SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration[1][2][3].

Product Specifications

CAS Number

[380572-02-1]

Product Name Alternative

1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105,Guanosine 5'-[β,γ-imido]triphosphate (trisodium)

UNSPSC

12352005

Target

Casein Kinase; SRPK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/srpin803.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(N=C1SC(C(F)(F)F)=NN1C/2=N)C2=C/C3=CC=C(C(OC)=C3)O

Molecular Formula

C14H9F3N4O3S

Molecular Weight

370.31

References & Citations

[1]Leonidis G, et, al. Synthesis and Biological Evaluation of a c (RGDyK) Peptide Conjugate of SRPIN803. ACS Omega. 2021 Oct 14;6 (42) :28379-28393.|[2]Vedove AD, et, al. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem. 2020 Jun 1;195:112267.|[3]Morooka S, et, al. Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.