Tert-Butyl 11-aminoundecanoate

Tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Product Specifications

CAS Number

[220851-29-6]

UNSPSC

12352211

Hazard Statement

H315, H318, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tert-butyl-11-aminoundecanoate.html

Purity

99.39

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC(C)(C)C)CCCCCCCCCCN

Molecular Formula

C15H31NO2

Molecular Weight

257.41

Precautions

H315, H318, H335

References & Citations

[1]Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9 (1) :19654.