2-Methylcitric acid (trisodium)

2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

Product Specifications

CAS Number

[117041-96-0]

Product Name Alternative

Methylcitric acid (trisodium)

UNSPSC

12352211

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-methylcitric-acid-trisodium.html

Purity

96.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CC(C(O[Na])=O)C(C(O[Na])=O)(O)CC(O[Na])=O

Molecular Formula

C7H7Na3O7

Molecular Weight

272.10

References & Citations

[1]Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185 (9) :2802-10.