CRBN ligand-9
CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM) . CRBN ligand-9 can be used for synthesis of PROTACs[1][2].
Product Specifications
CAS Number
[55003-81-1]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crbn-ligand-9.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC(CCC1N2C(C3=CC=C(C=C3C2=O)[N+](=O)[O-])=O)=O
Molecular Formula
C13H9N3O6
Molecular Weight
303.23
Precautions
H315, H319
References & Citations
[1]Heim C, et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62 (14) :6615-6629.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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