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Hydroxy-Dynasore

Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore , is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values ​​of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.

Product Specifications

CAS Number

1256493-34-1

Product Name Alternative

Dyngo-4a

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Dynamin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydroxy-dynasore.html

Purity

99.11

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O

Molecular Formula

C18H14N2O5

Molecular Weight

338.31

Precautions

H302, H312, H332

References & Citations

[1]Adam McCluskey, et al. Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis. Traffic. 2013 Dec;14 (12) :1272-89.|[2]Callista B Harper, et al.Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism.J Biol Chem. 2011 Oct 14;286 (41) :35966-76.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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