Hydroxy-Dynasore
Product Specifications
UNSPSC Description
Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
Target Antigen
Dynamin
Type
Reference compound
Related Pathways
Cytoskeleton
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hydroxy-dynasore.html
Smiles
OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O
Molecular Weight
338.31
References & Citations
[1]Adam McCluskey, et al. Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis. Traffic. 2013 Dec;14(12):1272-89.|[2]Callista B Harper, et al.Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism.J Biol Chem. 2011 Oct 14;286(41):35966-76.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13863/Hydroxy-Dynasore-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13863/Hydroxy-Dynasore-SDS-MedChemExpress.pdf
CAS Number
1256493-34-1
Available Sizes
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