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ROCK2-IN-8

ROCK2-IN-8 (Compound 1) is an orally active ROCK2 inhibitor, with an IC50 of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation[1].

Product Specifications

CAS Number

681173-76-2

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rock2-in-8.html

Purity

99.85

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(C1OC2=C(OC1)C=CC=C2)NC3=NC(C4=CC=NC=C4)=CS3

Molecular Formula

C17H13N3O3S

Molecular Weight

339.37

References & Citations

[1]Feng Y, et al. Discovery of substituted 4- (pyrazol-4-yl) -phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51 (21) :6642-5.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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