TFMB-(S)-2-HG
Product Specifications
UNSPSC Description
TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1].
Target Antigen
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tfmb-s-2-hg.html
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2
Molecular Weight
288.221
References & Citations
[1]Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129079A/TFMB-S-2-HG-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129079A/TFMB-S-2-HG-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1445703-64-9
Available Sizes
Curated Selection
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