TFMB- (S) -2-HG

TFMB- (S) -2-HG is a potent TET2 inhibitor. TFMB- (S) -2-HG also inhibits the EglN prolyl hydroxylases. TFMB- (S) -2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB- (S) -2-HG inhibits osteogenic differentiation of cells. TFMB- (S) -2-HG has the potential for the research of acute myeloid leukemia (AML) [1][2].

Product Specifications

CAS Number

[1445703-64-9]

UNSPSC

12352005

Target

DNA Methyltransferase; TET/FET Family; Wnt; β-catenin

Type

Reference compound

Related Pathways

Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/tfmb-s-2-hg.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2

Molecular Formula

C13H11F3O4

Molecular Weight

288.22

References & Citations

[1]Losman JA, et al. (R) -2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339 (6127) :1621-1625.|[2]Ding H, et al. Screening of differentially methylated genes in skeletal fluorosis of rats with different types and involvement of aberrant methylation of Cthrc1. Environ Pollut. 2023 Sep 1;332:121931.