ST91
ST91 is a α2-adrenoceptor (α2AR) agonist. ST91 activates both α2AAR and non-α2AAR subtypes to produce spinal antinociception[1][2][3].
Product Specifications
CAS Number
4749-61-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/st91.html
Purity
99.75
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCC1=C(NC2=NCCN2)C(CC)=CC=C1.[H]Cl
Molecular Formula
C13H20ClN3
Molecular Weight
253.77
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Graham BA, et, al. Synergistic interactions between two alpha (2) -adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain. 2000 Mar;85 (1-2) :135-43. |[2]Maccari S, et, al. α-Adrenoceptor stimulation attenuates melanoma growth in mice. Br J Pharmacol. 2022 Apr;179 (7) :1371-1383. |[3]Stone LS, et, al. ST91 [2- (2,6-diethylphenylamino) -2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors. J Pharmacol Exp Ther. 2007 Dec;323 (3) :899-906.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
Available Sizes
Frequently Asked Questions
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