PPIase-Parvulin inhibitor
PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs) [1].
Product Specifications
CAS Number
[64005-90-9]
UNSPSC
12352005
Hazard Statement
H400
Target
PIN1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ppiase-parvulin-inhibitor.html
Purity
99.79
Solubility
DMSO : ≥ 0.5 mg/mL
Smiles
O=C(N(CC(OCC)=O)C1=O)C2=CC=C(C3=C4C=CC1=C23)C(N(CC(OCC)=O)C4=O)=O
Molecular Formula
C22H18N2O8
Molecular Weight
438.39
Precautions
H400
References & Citations
[1]Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10 (1) :15-24.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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