SSO111 (sodium)
SSO111 sodium, a 20mer fully modified antisense oligonucleotide, targets the oncogene HER2. SSO111 sodium induces exon 15 skipping during splicing, leading to the generation of a novel mRNA transcript that excludes exon 15. SSO111 sodium downregulated HER2 mRNA, which resulted in the inhibition of proliferation and induction of apoptosis in HER2-overexpressing tumor cells.
Product Specifications
UNSPSC
12352208
Target
EGFR
Type
Oligonucleotides
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sso111-sodium.html
Solubility
10 mM in H2O
Smiles
[SSO111(sodium)]
References & Citations
[1]Wan J, Sazani P, Kole R. Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells. Int J Cancer. 2009;124 (4) :772-777. doi:10.1002/ijc.24052
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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