AUDA

AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively[1]. AUDA has anti-inflammatory activity[2].

Product Specifications

CAS Number

[479413-70-2]

UNSPSC

12352211

Hazard Statement

H302

Target

Epoxide Hydrolase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/auda.html

Purity

98.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CCCCCCCCCCCNC(NC1(C2)CC3CC2CC(C3)C1)=O

Molecular Formula

C23H40N2O3

Molecular Weight

392.58

Precautions

H302

References & Citations

[1]Morisseau C, et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases.Biochem Pharmacol. 2002 May 1;63 (9) :1599-608.|[2]Kim HS, et al. Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells.Int J Mol Sci. 2017 Dec 11;18 (12) .|[3]Dai N, et al. Vascular repair and anti-inflammatory effects of soluble epoxide hydrolase inhibitor.Exp Ther Med. 2019 May;17 (5) :3580-3588.