Alofanib
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2) . Anticancer and antiangiogenic activity[1][2].
Product Specifications
CAS Number
[1612888-66-0]
Product Name Alternative
RPT835
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Apoptosis; FGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Alofanib.html
Purity
99.90
Solubility
DMSO : ≥ 30.1 mg/mL
Smiles
O=C(O)C1=CC=CC(S(=O)(NC2=CC(C3=CC=CN=C3)=C(C)C=C2[N+]([O-])=O)=O)=C1
Molecular Formula
C19H15N3O6S
Molecular Weight
413.40
Precautions
H302, H312, H332
References & Citations
[1]Tsimafeyeu I, et al. Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models. Eur J Cancer. 2016 Jul;61:20-8.|[2]Khochenkov DA, et al. Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2. Bull Exp Biol Med. 2015 Nov;160 (1) :84-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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