Minodronic acid (hydrate)
Product Specifications
UNSPSC Description
Minodronic acid (YM-529) hydrate is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].
Target Antigen
Apoptosis; P2X Receptor
Type
Reference compound
Related Pathways
Apoptosis;Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minodronic-acid-hydrate.html
Solubility
H2O : 20 mg/mL (ultrasonic;adjust pH to 9 with 1 M NaOH)
Smiles
OC(P(O)(O)=O)(P(O)(O)=O)CC1=CN=C2C=CC=CN21.O
Molecular Weight
340.16
References & Citations
[1]Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61.|[2]Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16322A/Minodronic-acid-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16322A/Minodronic-acid-hydrate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
155648-60-5
Available Sizes
Curated Selection
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