Phenylthiourea
Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM) . Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation[1][2].
Product Specifications
CAS Number
103-85-5
Product Name Alternative
Phenylthiocarbamide
UNSPSC
12352005
Hazard Statement
H300, H317
Target
Endogenous Metabolite; Tyrosinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/phenylthiourea.html
Concentration
10mM
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C(NC1=CC=CC=C1)N
Molecular Formula
C7H8N2S
Molecular Weight
152.22
Precautions
H300, H317
References & Citations
[1]Ryazanova AD, et al. The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase. J Enzyme Inhib Med Chem. 2012 Feb;27 (1) :78-83.|[2]Frederick Bernheim & Mary L.C. Bernheim (1942) THE ACTION OF PHENYLTHIOCARBAMIDE ON TYROSINASE, Journal of Biological Chemistry, Volume 145, Issue 1, Pages 213-217, ISSN 0021-9258.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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