Phenylthiourea

Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM) . Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation[1][2].

Product Specifications

CAS Number

[103-85-5]

Product Name Alternative

Phenylthiocarbamide

UNSPSC

12352005

Hazard Statement

H300, H317

Target

Endogenous Metabolite; Tyrosinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/phenylthiourea.html

Concentration

10mM

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(NC1=CC=CC=C1)N

Molecular Formula

C7H8N2S

Molecular Weight

152.22

Precautions

H300, H317

References & Citations

[1]Ryazanova AD, et al. The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase. J Enzyme Inhib Med Chem. 2012 Feb;27 (1) :78-83.|[2]Frederick Bernheim & Mary L.C. Bernheim (1942) THE ACTION OF PHENYLTHIOCARBAMIDE ON TYROSINASE, Journal of Biological Chemistry, Volume 145, Issue 1, Pages 213-217, ISSN 0021-9258.