Asimilobine

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].

Product Specifications

CAS Number

[6871-21-2]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Parasite

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/asimilobine.html

Purity

99.9

Solubility

10 mM in DMSO

Smiles

OC1=C(OC)C2=C3C(CCN[C@]3([H])CC4=CC=CC=C24)=C1

Molecular Formula

C17H17NO2

Molecular Weight

267.32

References & Citations

[1]N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987;50 (4) :773-4.|[2]Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008;10 (7-8) :747-55.