BAL-0028
BAL-0028 is a reversible inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds closely to the NACHT domain of the NLRP3 with KD values of 104-123 nM. BAL-0028 can inhibit the secretion of IL-1β and has anti-inflammatory activity[1].
Product Specifications
CAS Number
2842012-69-3
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bal-0028.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
CN(C(C1=CC(OCC)=C(C2=CC(F)=CC=C2)C=C1)=O)CC3=C4C(C=NN4)=CC=C3
Molecular Formula
C24H22FN3O2
Molecular Weight
403.45
References & Citations
[1]Hartman G, et al. The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening. Bioorg Med Chem Lett. 2024 Feb 28;102:129675.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Available Sizes
Frequently Asked Questions
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