SIRT2/6-IN-1
SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1].
Product Specifications
CAS Number
[1214468-35-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase; Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sirt2-6-in-1.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC2=C(C=C1)NC(NC2=O)=O)(NC3=CC=C(C=C3)OC4=CC=CN=C4)=O
Molecular Formula
C19H14N4O5S
Molecular Weight
410.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57 (11) :4796-804.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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