Isoprocurcumenol

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].

Product Specifications

CAS Number

[102130-90-5]

Product Name Alternative

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

UNSPSC

12352211

Target

Akt; EGFR; ERK

Type

Natural Products

Related Pathways

JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/isoprocurcumenol.html

Purity

95.41

Smiles

O=C1CC([C@]2([H])CC[C@](C)(O)[C@@]2([H])C/C1=C(C)\C)=C

Molecular Formula

C15H22O2

Molecular Weight

234.33

References & Citations

[1]Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63 (1) :102-4.|[2]Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.) . Bioorg Med Chem Lett. 2018 Feb 1;28 (3) :410-414. |[3]Kwon PK, et al. Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. Int J Mol Sci. 2021 Nov 22;22 (22) :12579.