Isoprocurcumenol
Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].
Product Specifications
CAS Number
102130-90-5
Product Name Alternative
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
UNSPSC
12352211
Target
Akt; EGFR; ERK
Type
Natural Products
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/isoprocurcumenol.html
Purity
95.41
Smiles
O=C1CC([C@]2([H])CC[C@](C)(O)[C@@]2([H])C/C1=C(C)\C)=C
Molecular Formula
C15H22O2
Molecular Weight
234.33
References & Citations
[1]Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63 (1) :102-4.|[2]Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.) . Bioorg Med Chem Lett. 2018 Feb 1;28 (3) :410-414. |[3]Kwon PK, et al. Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. Int J Mol Sci. 2021 Nov 22;22 (22) :12579.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Akt; ERK
Available Sizes
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