Anpirtoline (hydrochloride)

Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2) . Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects[1][2][3].

Product Specifications

CAS Number

[99201-87-3]

Product Name Alternative

D-16949 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/anpirtoline-hydrochloride.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=NC(SC2CCNCC2)=CC=C1.Cl

Molecular Formula

C10H14Cl2N2S

Molecular Weight

265.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Swedberg MD, et al. D-16949 (anpirtoline) : a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effects in the rat. J Pharmacol Exp Ther. 1992 Dec;263 (3) :1015-22.|[2]Chien PY, et al. The dorsal raphe-to-ventral hippocampal projection modulates reactive aggression through 5-HT1B receptors. Eur J Pharmacol. 2024 Oct 15;981:176918.|[3]Schlicker E, et al. Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive/antidepressant-like actions in rodents. Br J Pharmacol. 1992 Mar;105 (3) :732-8.