KS176
KS176 is a selective BCRP inhibitor (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst assays, respectively) . KS176 can be used in the research of cancer[1][2][3].
Product Specifications
CAS Number
1253452-78-6
UNSPSC
12352005
Hazard Statement
H302
Target
BCRP
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KS176.html
Purity
99.09
Solubility
DMSO : ≥ 35 mg/mL
Smiles
O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)C=C2)=O)C=CC=C1)NC3=CC=C(CCO)C=C3
Molecular Formula
C22H19N3O5
Molecular Weight
405.40
Precautions
H302
References & Citations
[1]Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP) . ChemMedChem. 2010 Sep 3;5 (9) :1498-505.|[2]Cannon RE, et al. Tetrabromobisphenol A (TBBPA) Alters ABC Transport at the Blood-Brain Barrier. Toxicol Sci. 2019 Jun 1;169 (2) :475-484. |[3]Thomas JR, et al. Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier. Fluids Barriers CNS. 2024 Mar 15;21 (1) :27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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