Annexin A6/ANXA6, Human (His)

Annexin A6 Protein, Human (His) is a Annexin A6 protein fused to His-tag at N-terminus. Annexin A6 is an endogenous and secretory multifunctional protein and locates on the cell surface. Annexin A6 can be used for the study in mediating the endosome aggregation and vesicle fusion during exocytosis[1][2].

AKPAQGAKYR GSIHDFPGFD PNQDAEALYT AMKGFGSDKE AILDIITSRS NRQRQEVCQS YKSLYGKDLI ADLKYELTGK FERLIVGLMR PPAYCDAKEI KDAISGIGTD EKCLIEILAS RTNEQMHQLV AAYKDAYERD LEADIIGDTS GHFQKMLVVL LQGTREEDDV VSEDLVQQDV QDLYEAGELK WGTDEAQFIY ILGNRSKQHL RLVFDEYLKT TGKPIEASIR GELSGDFEKL MLAVVKCIRS TPEYFAERLF KAMKGLGTRD NTLIRIMVSR SELDMLDIRE IFRTKYEKSL YSMIKNDTSG EYKKTLLKLS GGDDDAAGQF FPEAAQVAYQ MWELSAVARV ELKGTVRPAN DFNPDADAKA LRKAMKGLGT DEDTIIDIIT HRSNVQRQQI RQTFKSHFGR DLMTDLKSEI SGDLARLILG LMMPPAHYDA KQLKKAMEGA GTDEKALIEI LATRTNAEIR AINEAYKEDY HKSLEDALSS DTSGHFRRIL ISLATGHREE GGENLDQARE DAQVAAEILE IADTPSGDKT SLETRFMTIL CTRSYPHLRR VFQEFIKMTN YDVEHTIKKE MSGDVRDAFV AIVQSVKNKP LFFADKLYKS MKGAGTDEKT LTRIMVSRSE IDLLNIRREF IEKYDKSLHQ AIEGDTSGDF LKALLALCGG ED

[1]Alexis R Demonbreun, et al. Recombinant annexin A6 promotes membrane repair and protects against muscle injury. J Clin Invest. 2019 Nov 1;129(11):4657-4670.|[2]Ramin Raouf, et al. Inhibition of somatosensory mechanotransduction by annexin A6. Sci Signal. 2018 Jun 19;11(535):eaao2060.|[3]Julie Leca, et al. Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness. J Clin Invest. 2016 Nov 1;126(11):4140-4156.