Human CellExp™ CD25/IL-2R alpha, C-His Tag, Human Recombinant

Interleukin-2 receptor subunit alpha (IL2RA) is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells. IL2RA binds IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covalently with the IL2 receptor beta and gamma chain, and subsequently initiates intracellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been considered as an activation marker. While both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.