CLK-IN-T3

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity[1].

Product Specifications

CAS Number

[2109805-56-1]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

CDK; DYRK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/clk-in-t3.html

Purity

98.63

Solubility

DMSO : 4.83 mg/mL (ultrasonic; warming)

Smiles

CC(C1=CC=C(C(NC2=CN3C=C(C4=CC=NC=C4)C=CC3=N2)=O)C=C1)(C)C(N5CCN(C)CC5)=O

Molecular Formula

C28H30N6O2

Molecular Weight

482.58

Precautions

H315, H319

References & Citations

[1]Funnell T, et al. CLK-dependent exon recognition and conjoined gene formation revealed with a novel smallmolecule inhibitor. Nat Commun. 2017 Feb 23;8 (1) :7.