CLK-IN-T3
CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity[1].
Product Specifications
CAS Number
[2109805-56-1]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
CDK; DYRK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clk-in-t3.html
Purity
98.63
Solubility
DMSO : 4.83 mg/mL (ultrasonic; warming)
Smiles
CC(C1=CC=C(C(NC2=CN3C=C(C4=CC=NC=C4)C=CC3=N2)=O)C=C1)(C)C(N5CCN(C)CC5)=O
Molecular Formula
C28H30N6O2
Molecular Weight
482.58
Precautions
H315, H319
References & Citations
[1]Funnell T, et al. CLK-dependent exon recognition and conjoined gene formation revealed with a novel smallmolecule inhibitor. Nat Commun. 2017 Feb 23;8 (1) :7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK
Available Sizes
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