SKLB70326
SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2.
Product Specifications
CAS Number
[1257317-77-3]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; CDK; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sklb70326.html
Smiles
O=C(N)C1=C(C2=CC=C(N=C2S1)C3=CC=CC(OC)=C3)N
Molecular Formula
C15H13N3O2S
Molecular Weight
299.35
References & Citations
[1]SKLB70326, a novel small-molecule inhibitor of cell-cycle progression, induces G₀/G₁ phase arrest and apoptosis in human hepatic carcinoma cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Browse additional items from our catalog
