SKLB70326
SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2.
Product Specifications
CAS Number
[1257317-77-3]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; CDK; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sklb70326.html
Smiles
O=C(N)C1=C(C2=CC=C(N=C2S1)C3=CC=CC(OC)=C3)N
Molecular Formula
C15H13N3O2S
Molecular Weight
299.35
References & Citations
[1]SKLB70326, a novel small-molecule inhibitor of cell-cycle progression, induces G₀/G₁ phase arrest and apoptosis in human hepatic carcinoma cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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