BAIAP2, Human recombinant

BAIAP2 is a ubiquitous regulator of the actin cytoskeleton. Controlled by the Rho-family GTPases BAIAP2 facilitates filopodia development. BAIAP2 is expressed in the cytoplasm and binds small membrane-bound G-proteins to cytoplasmic effector proteins and operates as an insulin receptor tyrosine kinase substrate. BAIAP2 proposes a part for insulin in the central nervous system and was identified as interacting with the dentatorubral pallidoluysian atrophy gene, which is related to an autosomal dominant neurodegenerative disease.