PKA cg, Active

PKA C-γ (PKAcg) is a third isoform of the catalytic subunit of cAMP-dependent protein kinase. It was isolated from a human testis cDNA library and was clearly derived from a gene distinct from C-α and C-β and showed tissue-specific expression. Whereas at the amino acid level C-α and C-β showed 93% homology, C-γ showed only about 80% homology to both C-α and C-β (1). The PRKACG gene is intronless, contains remnants of a poly (A) tail, is flanked by direct repeats, and is co-linear with the PRKACA gene(2).