Ac-DEVD-CHO
Ac-DEVD-CHO is a Caspase-3 inhibitor with a Ki value of 230 pM.
Product Specifications
CAS Number
169332-60-9
UNSPSC
12352209
Hazard Statement
H302, H312, H332
Target
Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ac-DEVD-CHO.html
Purity
99.76
Solubility
10 mM in DMSO|H2O : ≥ 50 mg/mL
Smiles
O=C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O
Molecular Formula
C20H30N4O11
Molecular Weight
502.47
Precautions
H302, H312, H332
References & Citations
[1]Garcia-Calvo M, et al.nhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem. 1998 Dec 4;273 (49) :32608-13.|[2]Jinglin Wang, et al. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. Oncotarget. 2017 Jan 3; 8 (1) : 610-623.|[3]Junping Zhang, et al. Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro. Cancer Cell Int. 2015; 15: 58|[4]Long-gang He, et al. Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation. Acta Pharmacol Sin. 2014 Feb; 35 (2) : 203-210.|[5]Liu LX, et al. The effect of caspase-3 inhibitor on the concentrations of serum inflammatory cytokines in sepsis related acute kidney injury induced by peritoneal cavity infection in mice. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Dec;22 (12) :736-9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; Caspase 10; Caspase 2; Caspase 3; Caspase 4; Caspase 5; Caspase 6; Caspase 7; Caspase 8; Caspase 9
Available Sizes
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