Ac-DEVD-CHO

Ac-DEVD-CHO is a Caspase-3 inhibitor with a Ki value of 230 pM.

Product Specifications

CAS Number

[169332-60-9]

UNSPSC

12352209

Hazard Statement

H302, H312, H332

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Ac-DEVD-CHO.html

Purity

99.76

Solubility

10 mM in DMSO|H2O : ≥ 50 mg/mL

Smiles

O=C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O

Molecular Formula

C20H30N4O11

Molecular Weight

502.47

Precautions

H302, H312, H332

References & Citations

[1]Garcia-Calvo M, et al.nhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem. 1998 Dec 4;273 (49) :32608-13.|[2]Jinglin Wang, et al. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. Oncotarget. 2017 Jan 3; 8 (1) : 610-623.|[3]Junping Zhang, et al. Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro. Cancer Cell Int. 2015; 15: 58|[4]Long-gang He, et al. Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation. Acta Pharmacol Sin. 2014 Feb; 35 (2) : 203-210.|[5]Liu LX, et al. The effect of caspase-3 inhibitor on the concentrations of serum inflammatory cytokines in sepsis related acute kidney injury induced by peritoneal cavity infection in mice. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Dec;22 (12) :736-9.