MK-4882
MK-4882 is an HCV NS5A inhibitor with activity in reducing viral load in a chimpanzee model of HCV infection, but with issues of viral breakthrough, prompting the development of compounds with greater potency against more genotypes and NS5A resistance mutations[1].
Product Specifications
CAS Number
1246470-32-5
UNSPSC
12352005
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/mk-4882.html
Smiles
O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C2=NC=C(N2)C3=CC=C(C=C3)C4=CC5=CC(C6=CN=C(N6)[C@H]7N(CCC7)C([C@H](C(C)C)NC(OC)=O)=O)=CC=C5O4)=O)OC
Molecular Formula
C42H50N8O7
Molecular Weight
778.90
References & Citations
[1]Discovery of potent macrocyclic HCV NS5A inhibitors|[2]Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity|[3]Discovery and development of hepatitis C virus NS5A replication complex inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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