Metopimazine acid-d6 (hydrochloride)
Metopimazine-d6 hydrochloride is the deuterium labeled Metopimazine. Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks[1][2][3][4].
Product Specifications
UNSPSC
12352005
Target
Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C(C1CCN(C([2H])([2H])C([2H])([2H])C([2H])(N2C3=C(C=CC=C3)SC4=CC=C(S(=O)(C)=O)C=C24)[2H])CC1)O.Cl
Molecular Formula
C22H21D6ClN2O4S2
Molecular Weight
489.08
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
D2 Receptor
Available Sizes
Frequently Asked Questions
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