Carbonic Anhydrase 8, Human (His)

Carbonic Anhydrase VIII/CA8 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Carbonic anhydrase 8 (CA8), an isozyme of α-carbonic anhydrases (CAs), is an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1), which regulates neuronal intracellular calcium release[1][2].

ADLSFIEDTV AFPEKEEDEE EEEEGVEWGY EEGVEWGLVF PDANGEYQSP INLNSREARY DPSLLDVRLS PNYVVCRDCE VTNDGHTIQV ILKSKSVLSG GPLPQGHEFE LYEVRFHWGR ENQRGSEHTV NFKAFPMELH LIHWNSTLFG SIDEAVGKPH GIAIIALFVQ IGKEHVGLKA VTEILQDIQY KGKSKTIPCF NPNTLLPDPL LRDYWVYEGS LTIPPCSEGV TWILFRYPLT ISQLQIEEFR RLRTHVKGAE LVEGCDGILG DNFRPTQPLS DRVIRAAFQH HHHHH

[1]Gerald Z Zhuang, et al. Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. Gene Ther. 2018 Jul;25(4):297-311.|[2]Min-Syuan Huang, et al. Roles of carbonic anhydrase 8 in neuronal cells and zebrafish. Biochim Biophys Acta. 2014 Sep;1840(9):2829-42.