MLi-2

MLi-2, a chemical probe, is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinson’s disease[1].

Product Specifications

CAS Number

[1627091-47-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/MLi-2.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@](C1)([H])O[C@](C)([H])CN1C2=CC(C3=NNC4=CC=C(OC5(C)CC5)C=C43)=NC=N2

Molecular Formula

C21H25N5O2

Molecular Weight

379.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Fell MJ, et al. MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition. J Pharmacol Exp Ther. 2015 Dec;355 (3) :397-409.