MCU-i11

MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth. MCU-i11 can be used to study breast cancer, cervical cancer and neurological diseases[1][2][3].

Product Specifications

CAS Number

[902903-59-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mcu-i11.html

Purity

98.42

Solubility

DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=C(OCC)C=C1)CN2C(N(CC3=CC=CC=C3)C(C4=C2SC5=C4CCN(C(C)=O)C5)=O)=O

Molecular Formula

C28H28N4O5S

Molecular Weight

532.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Di Marco G, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30 (7) :2321-2331.e6.|[2]Marmolejo-Garza A, et al. Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. Cell Death Dis. 2023 Nov 25;14 (11) :772.|[3]Serrat R, et al. Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration. Cell Rep. 2021 Dec 21;37 (12) :110133.