Coptisine (chloride)
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6 μg/mL and can be used for influenza A (H1N1) infection.
Product Specifications
CAS Number
6020-18-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Indoleamine 2,3-Dioxygenase (IDO) ; Influenza Virus
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Coptisine-chloride.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 7.94 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6.[Cl-]
Molecular Formula
C19H14ClNO4
Molecular Weight
355.77
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IDO
Citation 01
Available Sizes
Frequently Asked Questions
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