Human Recombinant Carbonic anhydrase 2

The enzyme Carbonic anhydrase 2 (CA2) is a part of the enzyme family that catalyses rapid inter-conversion of carbon dioxide & water to bicarbonate, carbonic acid and protons (CO2 + H2O to HCO3 + H), a reaction that occurs rather slowly in the absence of a catalyst. The majority of carbonic anhydrases enclose a zinc ion in their active site and therefore is classified as metalloenzymes. The most important function of Carbonic anhydrase is known to preserve acid-base balance in blood and other tissues, and to help transport carbon dioxide of tissues. Carbonic anhydrases have been found in all kingdoms of life. Mammalian carbonic anhydrase is monomeric and belongs to the alpha class. Mutations in the CA2 gene result in the CA2 deficiency syndrome, an autosomal recessive disorder that produces osteoporosis, renal tubular acidosis and cerebral calcification.