YF-2 (hydrochloride)
YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].
Product Specifications
CAS Number
[1312005-62-1]
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/YF-2_hydrochloride.html
Concentration
10mM
Purity
99.29
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 3.12 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C.Cl
Molecular Formula
C20H23Cl2F3N2O3
Molecular Weight
467.31
References & Citations
[1]FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; GCN5/PCAF
Available Sizes
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