FTY720 (S) -Phosphate

FTY720 (S) -Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

Product Specifications

CAS Number

[402616-26-6]

Product Name Alternative

(S) -FTY720P; (S) -FTY720 phosphate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H336

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/FTY720__S_-Phosphate.html

Purity

99.57

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : < 0.1 mg/mL

Smiles

OC[C@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O

Molecular Formula

C19H34NO5P

Molecular Weight

387.45

Precautions

H302, H315, H319, H335, H336

References & Citations

[1]Wang L, et al. FTY720 (s) -phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42 (3) :e189-99.|[2]Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345.