RELM-alpha, murine recombinant

RELM-α belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELM-α and Resistin are secreted exclusively by adipocytes while RELM-β is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELM-α re still unknown. Recombinant murine RELM-α is a 10.0 kDa monomeric protein containing 88 amino acid residues.