SR 11023
SR 11023 is an orally active antagonist of PPARγ, with the IC50 value of 109 nM that plays an important role in diabetic research[1].
Product Specifications
CAS Number
1820602-13-8
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sr-11023.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC(C2CC2)=CC=C1)NC(C3=CC=C(C(C(C)=C4C)=C3)N4CC5=CC=C(C=C5)C(C)(C)C(O)=O)=O
Molecular Formula
C33H36N2O3
Molecular Weight
508.65
References & Citations
[1]J Mukherjee, et al. Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism. Nucl Med Biol. 1995 Apr;22 (3) :283-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
B2016045 10 µg
Anti Rat CD3 Antibody Conjugated to PerCP/Cyanine5.5
Sign In for Pricing
View Details QP9287-ye-500ug 500ug
Recombinant Human CD20/ MS4A1 Protein, His, Yeast-500ug
Sign In for Pricing
View Details