Periostin/OSF-2, human recombinant

Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor β1 (TGF-β1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors. BioVision’s Periostin is a His-Tagged fusion protein produced in E. coli, containing 648 amino acid residues of the human Periostin and 23 additional amino acid residues - HisTag, Xa - cleavage site.