IL-12, human recombinant

IL-12 is a potent regulator of cell mediated immune responses and in induces IFN- production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN- producing Th1 cells. Recombinant human IL-12 is a 75 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).