NSC-311068
Product Specifications
UNSPSC Description
NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1[1].
Target Antigen
TET Protein
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-311068.html
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
[O-][N+](C1=CC=C(C([N+]([O-])=O)=C1)SC2=CC=NC=N2)=O
Molecular Weight
278.24
References & Citations
[1]Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160638/NSC-311068-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160638/NSC-311068-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
73768-68-0
Available Sizes
Curated Selection
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