NSC-311068

NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1[1].

Product Specifications

CAS Number

[73768-68-0]

UNSPSC

12352005

Target

TET Protein

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc-311068.html

Purity

98.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

[O-][N+](C1=CC=C(C([N+]([O-])=O)=C1)SC2=CC=NC=N2)=O

Molecular Formula

C10H6N4O4S

Molecular Weight

278.24

References & Citations

[1]Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8 (1) :2099.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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